Description

Letrozole Tablets USP 2.5 mg

Letrozole Tablets USP 2.5 mg contain Letrozole 2.5 mg, an aromatase inhibitor used primarily in the treatment of hormone receptor-positive breast cancer in postmenopausal women. Letrozole reduces the body’s production of estrogen, which can help slow the growth of estrogen-dependent breast cancer cells.

Letrozole may be prescribed as adjuvant treatment after initial breast cancer therapy, for extended adjuvant treatment, or for advanced/metastatic hormone receptor-positive breast cancer depending on the patient’s clinical situation.

Product Information

Product Name	Letrozole Tablets USP 2.5 mg
Generic Name	Letrozole
Strength	2.5 mg
Drug Class	Aromatase Inhibitor
Therapeutic Use	Hormone Receptor-Positive Breast Cancer
Dosage Form	Tablet
Route of Administration	Oral
Prescription Status	Prescription Medicine

Uses of Letrozole 2.5 mg

Letrozole may be prescribed for:

• Hormone receptor-positive early breast cancer in postmenopausal women

• Adjuvant treatment following initial breast cancer treatment

• Extended adjuvant treatment after previous tamoxifen therapy

• Locally advanced or metastatic hormone receptor-positive breast cancer

• Certain hormone-sensitive breast cancer treatment situations determined by an oncologist

The exact indication depends on the patient’s cancer characteristics, menopausal status, previous treatments, and medical assessment.

How Letrozole 2.5 mg Works

Letrozole is a non-steroidal aromatase inhibitor.

After menopause, estrogen is produced primarily through conversion of androgens into estrogen by an enzyme called aromatase. Letrozole inhibits aromatase, substantially reducing estrogen production.

Lower estrogen levels can slow or inhibit the growth of breast cancer cells that depend on estrogen.

Benefits of Letrozole 2.5 mg

• Helps reduce estrogen production in postmenopausal women

• Helps slow the growth of hormone-sensitive breast cancer

• Used as adjuvant therapy to reduce the risk of breast cancer recurrence in appropriate patients

• Can be used in certain advanced or metastatic breast cancer treatment regimens

• Provides targeted hormonal treatment without directly acting as conventional cytotoxic chemotherapy

Directions for Use

Take Letrozole 2.5 mg exactly as prescribed by your oncologist.

The usual dose for breast cancer treatment is 2.5 mg once daily, but the duration of treatment varies according to the treatment plan and individual circumstances.

The tablet can generally be taken with or without food. Try to take it at approximately the same time each day.

If you miss a dose, follow your healthcare professional’s instructions. Do not take an extra dose unless specifically advised.

Possible Side Effects

Common side effects may include:

• Hot flushes

• Increased sweating

• Joint pain

• Muscle pain

• Bone or back pain

• Fatigue

• Headache

• Dizziness

• Nausea

• Increased cholesterol

• Mood changes

Because letrozole reduces estrogen levels, prolonged treatment can contribute to bone loss and osteoporosis.

Serious Side Effects

Seek medical attention for severe or persistent symptoms such as:

• Severe chest pain or difficulty breathing

• Sudden weakness or neurological symptoms

• Severe allergic reactions

• Significant bone pain or fractures

• Severe liver-related symptoms

Your healthcare professional may monitor bone health, cholesterol levels, and other relevant parameters during long-term treatment.

Precautions

Tell your doctor if you have:

• Osteoporosis or low bone density

• A history of fractures

• High cholesterol

• Liver disease

• Kidney disease

• Cardiovascular disease

• Other significant medical conditions

Letrozole is generally intended for postmenopausal women for breast cancer treatment. It should not be used during pregnancy because reducing estrogen production can harm the developing fetus.

Your doctor may recommend bone-density testing and calcium/vitamin D supplementation or other bone-protective treatment when appropriate.

Inform your healthcare professional about all prescription medicines, over-the-counter medicines, and supplements you use.

Frequently Asked Questions

What is Letrozole 2.5 mg used for?

Letrozole 2.5 mg is primarily used to treat certain hormone receptor-positive breast cancers, particularly in postmenopausal women.

What is the generic name of Letrozole Tablets USP 2.5 mg?

The active ingredient is Letrozole 2.5 mg.

What type of medicine is letrozole?

Letrozole is a non-steroidal aromatase inhibitor and belongs to the hormonal anticancer medicine class.

How does Letrozole 2.5 mg work?

It blocks the aromatase enzyme, reducing estrogen production. This can slow the growth of breast cancer cells that depend on estrogen.

How often is Letrozole 2.5 mg taken?

The usual breast-cancer treatment dose is 2.5 mg once daily. The duration and exact treatment plan should be determined by the treating oncologist.

Can Letrozole cause joint pain?

Yes. Joint and muscle pain are relatively common with aromatase inhibitor treatment.

Can Letrozole affect bone health?

Yes. Long-term estrogen reduction can decrease bone mineral density and increase the risk of osteoporosis and fractures. Your doctor may monitor bone density during treatment.

Can Letrozole be taken with food?

Yes. Letrozole tablets can generally be taken with or without food. Follow the instructions provided by your healthcare professional or product label.

Can Letrozole be used during pregnancy?

No. Letrozole can cause fetal harm and should not be used during pregnancy unless specifically directed for an appropriate medical indication by a specialist.

Is Letrozole 2.5 mg a chemotherapy medicine?

Letrozole is not conventional cytotoxic chemotherapy. It is a hormonal anticancer therapy that reduces estrogen production.

Is Letrozole 2.5 mg a prescription medicine?

Yes. Letrozole should be used under the supervision of an oncologist or other qualified healthcare professional.